The development of the tuberculin test required first a standardization of the tuberculin.  Seibert's work accomplished this with the purification of tuberculin.  The amount of tuberculin that was required to elicit a tuberculin skin test reaction had to be determined.

It was obvious that among all the different administration techniques, the intradermal application of tuberculin allowed the most correct dosing.

It had to be agreed upon what exactly should be measured.

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