| For
the comprehension of interventions for tuberculosis control and
elimination, the same model as proposed for the epidemiology of
tuberculosis is utilized.
Interventions for tuberculosis control are
interventions that reduce the incidence of infection with M.
tuberculosis. Interventions for tuberculosis elimination
are interventions that reduce the prevalence of infection with M.
tuberculosis.
Chemotherapy of tuberculosis has two
effects. Individually, it reduces the risk of death from
tuberculosis and restores health. Epidemiologically, it interferes
with transmission, reducing exposure time in the community and thus the
incidence of infection with M. tuberculosis.
Prophylactic treatment is defined as the
provision of treatment for a person exposed but not yet infected with M.
tuberculosis with the aim to reduce the risk of acquisition of
infection. Prophylactic treatment reduces thus the incidence of
infection.
Preventive therapy is defined as the
provision of treatment to a person already infected with M.
tuberculosis with the aim to reduce the risk of progression from
subclinical, latent infection to overt clinical tuberculosis.
Preventive therapy reduces thus the incidence of infection.
BCG vaccination must be given before
infection with M. tuberculosis has been acquired. Its aim is
to reduce the risk of progression from latent infection to tuberculosis in
case such infection is acquired subsequent to vaccination. Its
expected effect is thus similar to one that reduces the prevalence of
infection.
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